$ ls -lh /System/Library/Frameworks/AppKit.framework/Versions/Current/AppKit
ls: /System/Library/Frameworks/AppKit.framework/Versions/Current/AppKit: No such file or directory

WTF, mate?

Invariably I spend half an hour websearching around to try to figure out how the hell my system got so broken, and how it’s possible to even boot macOS in such a corrupt state, until finally I chance upon Michael Tsai’s excellent summary of how Apple broke their frameworks starting in Big Sur.

The good news for Hopper is that it has since been updated to work around this – you can access the Apple framework binaries through File > Read File from DYLD Cache… There’s also tools like dyld-shared-cache-extractor which can resurrect the binaries from the cache.

Note also that in Sonoma, at least, the cache lives at /System/Volumes/Preboot/Cryptexes/OS/System/Library/dyld/ (in previous macOS releases it was apparently in /System/Library/dyld/).